We have developed dendritic "molecular glues" G1(Gu⁺)₉R, bearing nine guanidinium units, which are able to adhere to biomacromolecules via a multivalent salt-bridge formation with oxyanion functionalities. By this adhesion mechanism, G1(Gu⁺)₉R not only stabilizes protein assemblies such as microtubules, but also decelerates or totally arrests the ATP-driven sliding motion of actin filaments on a myosin-immobilized coverslip.